Defining the Inflammation Biomarkers of Inflammatory Bowel Diseases (IBD) and Colorectal Carcinomas (CRC)

Ulcerative colitis (UC) and Crohn’s disease (CD) are the two common forms of inflammatory bowel disease (IBD). They share similar clinical and demographic features as well as harbor key differences in tissue damage and prognosis. Previous studies indicated that they contributed to the increased rick to Colorectal cancer (CRC). However, whether UC and CD share inflammatory signatures still remains controversial. In addition, no inflammatory signatures have been reported on CRC. To answer these questions, a comprehensive study has been conducted on collected microarray datasets. Our analysis suggests that although CD and UC share common inflammatory pathways, they also present difference. Especially, CD patients are likely to have type I response, while UC patients are inclined to undergo type II response. Pathway enrichment analysis on CRC uncovered two potential CRC-specific inflammatory pathways. INDEX WORDS: Ulcerative colitis (UC), Crohn’s disease (CD), Inflammatory bowel disease (IBD), Colorectal cancer (CRC), Microarray, Pathway. DEFINING THE INFLAMMATION BIOMARKERS OF INFLAMMATORY BOWEL DISEASES (IBD) AND COLORECTAL CARCINOMAS (CRC)